2025

Design and Analysis of Novel HEV Vaccine Variants and Evaluation of Two Selected Candidates in a Porcine Infection Model. 
Hrabal I, Aliabadi E, Weber S, Ssebyatika GL, Krey T, Holicki CM, Schmid L, Dinkelborg K, Schröder C, Fast C, Behrendt P, Groschup MH, Eiden M.
Liver Int. 2025 Sep;45(9):e70246. doi: 10.1111/liv.70246. PMID: 40747926

In vivo evolution of ceftazidime-avibactam resistance in bla _OXA-244 -positive E. coli potentially linked to PBP3 insertion and mutations in acrB and PBP2. 
Kocer K, Boutin S, Hansen G, Nurjadi D, Weidner NM.
JAC Antimicrob Resist. 2025 Aug 1;7(4):dlaf137. doi: 10.1093/jacamr/dlaf137. eCollection 2025 Aug. PMID: 40756421

Rolf Peter Hilgenfeld (1954–2025)
Mesters JR
Acta Cryst. D81, pp. 469-472, August 2025. doi: 10.1107/S2059798325006424 Obituary

A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs. 
Stein SC, Ssebyatika G, Benecke T, Ströh L, Rajak MK, Vollmer B, Menz S, Waldmann J-Y, Tipp SN, Ochulor O, Herold E, Schwarzloh B, Mutschall D, Zischke J, Schneider T, Hinrichs I, Blasczyk R, Kleine-Weber H, Hoffmann M, Klein F, Kaiser FK, Gonzalez-Hernandez M, Armando F, Ciurkiewicz M, Beythien G, Pöhlmann S, Baumgärtner W, Gruenewald K, Osterhaus A, Schulz TF, Krey T, Hansen G.
mBio. 2025 Sep 10;16(9):e0060625. doi: 10.1128/mbio.00606-25. Epub 2025 Jul 31. PMID: 40742150

Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity. 
Thiessen L, Garuti R, Kubic L, Kösters M, Amarambedu Selvakumar D, Krey T, Görzer I, Fröhlich T, Adler B.
PLoS Pathog. 2025 Jul 24;21(7):e1013341. doi: 10.1371/journal.ppat.1013341. eCollection 2025 Jul. PMID: 40705828

The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.
Reuter M, Parry RH, McFarlane M, Gestuveo RJ, Arif R, Khromykh AA, Brennan B, Varjak M, Castello A, Redecke L, Schnettler E, Kohl A.
RNA. 2025 Apr 16;31(5):679-691. doi: 10.1261/rna.080149.124. PMID: 39947927; PMCID: PMC12001973.

Intracellular protein crystallization in living insect cells.
Schönherr R, Eichler N, Sornaly FA, Boger J, Frevert AM, Lahey-Rudolph JM, Meyer H, Weymar L, Redecke L. 
FEBS Open Bio. 2025 Apr;15(4):551-562. doi: 10.1002/2211-5463.70020. Epub 2025 Mar 28. PMID: 40153432; PMCID: PMC11961387

Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice.
Ssebyatika G, Dinkelborg K, Ströh LJ, Hinte F, Corneillie L, Hueffner L, Guzman EM, Nankya PL, Plückebaum N, Fehlau L, Garn J, Meyer N, Prallet S, Mehnert AK, Kraft ARM, Verhoye L, Jacobsen C, Steinmann E, Wedemeyer H, Viejo-Borbolla A, Dao Thi VL, Pietschmann T, Lütgehetmann M, Meuleman P, Dandri M, Krey T, Behrendt P.
Nat Commun. 2025 Feb 26;16(1):1995. doi: 10.1038/s41467-025-57182-1. PMID: 40011441

The catalytic tetrad of Aedes aegypti argonaute 2 is critical for the antiviral activity of the exogenous siRNA pathway.
Dummunee K, Parry RH, Redecke L, Varjak M, Brennan B, Kohl A, McFarlane M.
J Biol Chem. 2025 Apr;301(4):108332. doi: 10.1016/j.jbc.2025.108332. Epub 2025 Feb 19. PMID: 39984048; PMCID: PMC11968273

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies. 
Wehrle S, Scheck A, Reusch L, Matassoli F, Georgeon S, Castro KM, Cramer J, Harshbarger W, Rosset S, Andrews SF, Schön K, Bouzya B, Rouxel R, Blais N, Malito E, McDermott A, Krey T, Mallett CP, Vassilev V, Angeletti D, Correia BE.
bioRxiv [Preprint]. 2025 Jan 22:2025.01.22.634229. doi: 10.1101/2025.01.22.634229. PMID: 40568086