2025
Design and Analysis of Novel HEV Vaccine Variants and Evaluation of Two Selected Candidates in a Porcine Infection Model.
Hrabal I, Aliabadi E, Weber S, Ssebyatika GL, Krey T, Holicki CM, Schmid L, Dinkelborg K, Schröder C, Fast C, Behrendt P, Groschup MH, Eiden M.
Liver Int. 2025 Sep;45(9):e70246. doi: 10.1111/liv.70246. PMID: 40747926
In vivo evolution of ceftazidime-avibactam resistance in bla OXA-244 -positive E. coli potentially linked to PBP3 insertion and mutations in acrB and PBP2.
Kocer K, Boutin S, Hansen G, Nurjadi D, Weidner NM.
JAC Antimicrob Resist. 2025 Aug 1;7(4):dlaf137. doi: 10.1093/jacamr/dlaf137. eCollection 2025 Aug. PMID: 40756421
Rolf Peter Hilgenfeld (1954–2025)
Mesters JR
Acta Cryst. D81, pp. 469-472, August 2025. doi: 10.1107/S2059798325006424 Obituary
A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs.
Stein SC, Ssebyatika G, Benecke T, Ströh L, Rajak MK, Vollmer B, Menz S, Waldmann J-Y, Tipp SN, Ochulor O, Herold E, Schwarzloh B, Mutschall D, Zischke J, Schneider T, Hinrichs I, Blasczyk R, Kleine-Weber H, Hoffmann M, Klein F, Kaiser FK, Gonzalez-Hernandez M, Armando F, Ciurkiewicz M, Beythien G, Pöhlmann S, Baumgärtner W, Gruenewald K, Osterhaus A, Schulz TF, Krey T, Hansen G.
mBio. 2025 Jul 31:e0060625. doi: 10.1128/mbio.00606-25. Online ahead of print. PMID: 40742150
Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity.
Thiessen L, Garuti R, Kubic L, Kösters M, Amarambedu Selvakumar D, Krey T, Görzer I, Fröhlich T, Adler B.
PLoS Pathog. 2025 Jul 24;21(7):e1013341. doi: 10.1371/journal.ppat.1013341. eCollection 2025 Jul. PMID: 40705828
Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice.
Ssebyatika G, Dinkelborg K, Ströh LJ, Hinte F, Corneillie L, Hueffner L, Guzman EM, Nankya PL, Plückebaum N, Fehlau L, Garn J, Meyer N, Prallet S, Mehnert AK, Kraft ARM, Verhoye L, Jacobsen C, Steinmann E, Wedemeyer H, Viejo-Borbolla A, Dao Thi VL, Pietschmann T, Lütgehetmann M, Meuleman P, Dandri M, Krey T, Behrendt P.
Nat Commun. 2025 Feb 26;16(1):1995. doi: 10.1038/s41467-025-57182-1. PMID: 40011441
Computationally designed stem-epitope mimetics elicit broadly reactive antibodies.
Wehrle S, Scheck A, Reusch L, Matassoli F, Georgeon S, Castro KM, Cramer J, Harshbarger W, Rosset S, Andrews SF, Schön K, Bouzya B, Rouxel R, Blais N, Malito E, McDermott A, Krey T, Mallett CP, Vassilev V, Angeletti D, Correia BE.
bioRxiv [Preprint]. 2025 Jan 22:2025.01.22.634229. doi: 10.1101/2025.01.22.634229. PMID: 40568086
