R. Hilgenfeld:
Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia.
Future Med. Chem. 2, 1061 - 1067 (2010) (commentary).

J. Rohayem, M. Bergmann, J. Gebhardt, E. Gould, P. Tucker, A. Mattevi, T. Unge, R. Hilgenfeld & J. Neyts:
Antiviral strategies to control calicivirus infections.
Antiviral Res. [Epub: May 13, 2010].

E. Wexselblatt, J. Katzhendler, R. Saleem-Batcha, G. Hansen, R. Hilgenfeld, G. Glaser & R. Vidavski:
ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria.
Bioorg Med Chem., in the press [Epub: April 29, 2010].

A. Rennenberg, C. Lehmann, A. Heitmann, T. Witt, G. Hansen, K. Nagarajan, C. Deschermeier, V. Turk, R. Hilgenfeld & V.T. Heussler:
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.
PLoS Pathog. 6, e1000825 (2010).

H. Steuber & R. Hilgenfeld:
Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals.
Curr Top Med Chem. 23, 323-345 (2010).

S. Chen, F. Jonas, C. Shen & R. Hilgenfeld:
Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.
Protein & Cell 1, 59-74 (2010).

N. Petermann, G. Hansen, C.L. Schmidt & R. Hilgenfeld:
Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila.
FEBS Lett. 584, 733-738 (2010).

J.A. Wojdyla, I. Manolaridis, E.J. Snijder, A.E. Gorbalenya, B. Coutard, Y. Piotrowski, R. Hilgenfeld & P.A. Tucker:
Structure of the X (ADRP) domain of nsp3 from feline coronavirus.
Acta Cryst. D65, 1292–1300 (2009).

E. Liebau, K.F. Dawood, R. Fabrini, L. Fisher-Riepe, M. Perbandt, L. Stella, J.Z. Pedersen, A. Bocedi, P. Petrarca, G. Federici & G. Ricci:
Tetramerization and cooperativity in plasmodium falciparum glutathione transferase are mediated by the atypic loop 113-119.
J. Biol. Chem. 284, 22133-22139 (2009).

X. Tian, G. Lu, F. Gao, H. Peng, Y. Feng, G. Ma, M. Bartlam, K. Tian, J. Yan, R. Hilgenfeld & G.F. Gao:
Structure and cleavage-specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).
J. Mol. Biol. 392, 977-993 (2009).

H. Li, J. Huang, L. Chen, X. Liu, T. Chen, J. Zhu, W. Lu, X. Shen, J. Li, R. Hilgenfeld & H. Jiang:
Identification of Novel Falcipain-2 Inhibitors as Potential Antimalarial Agents through Structure-Based Virtual Screening.
J. Med. Chem. 52, 4936-4940 (2009).

J. Wolfova, I.K. Smatanova, J. Brynda, J.R. Mesters, M. Lapkouski, M. Kuty, A. Natalello, N. Chatterjee, S.-Y. Chern, E. Ebbel, A. Ricci, R. Grandori, R. Ettrich, & J. Carey:
Structural organization of WrbA in apo- and holo-protein crystals.
BBA-Proteins Proteom. 9, 1288-1298 (2009).

U. Mamat, H. Schmidt, E. Munoz, B. Lindner, K. Fukase, A. Hanuszkiewicz, J. Wu, T.C. Meredith, R.W. Woodard, R. Hilgenfeld, J.R. Mesters & O. Holst:
WaaA of the hyperthermophilic bacterium aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis.
J. Biol. Chem. 284, 22248-62, (2009).

P. Asanithi, E. Saridakis, L. Govada, I. Jurewicz, E.W. Brunner, R. Ponnusamy, J.A.S. Cleaver, A.B. Dalton, N.E. Chayen & R.P. Sear:
Carbon-Nanotube-Based Materials for Protein Crystallization.
ACS Appl. Mater. Interfaces. 6,1203–1210 (2009).

J. Tan, C. Vonrhein, O.S. Smart, G. Bricogne, M. Bollati, Y. Kusov, G. Hansen, J.R. Mesters, C.L. Schmidt & R. Hilgenfeld:
The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.
PLoS Pathog. 5, e1000428 (2009). (movie at www.scivee.tv)

A. Eichert, A. Schreiber, J.P. Fürste, M. Perbandt, C. Betzel, V.A. Erdmann & C. Förster:
Escherichia coli tRNAArg acceptor-stem isoacceptors: comparative crystallization and preliminary X-ray diffraction analysis.
Acta Cryst. Sect F Struct Biol Cryst Commun. 65, 98-101 (2009).

A. Eichert, M. Perbandt, A. Schreiber, J.P. Fürste, C. Betzel, V.A. Erdmann & C. Förster:
X-ray diffraction analysis of a human tRNA(Gly) acceptor-stem microhelix isoacceptor at 1.18 A resolution.
Acta Cryst. Sect F Struct Biol Cryst Commun. 65, 59-62 (2009).

Y. Piotrowski, G. Hansen, A.L. Boomaars-van der Zanden, E.J. Snijder, A.E. Gorbalenya & R. Hilgenfeld:
Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.
Prot. Sci. 18, 6-16 (2009).

E. Liebau, J. Höppner, M. Mühlmeister, C. Burmeister, K. Lüersen, M. Perbandt, C. Schmetz, D. Büttner & N. Brattig:
The secretory omega-class glutathione transferase OvGST3 from the human pathogenic parasite Onchocerca volvulus.
FEBS J. 275, 3438-3453 (2008).

M. Perbandt, J. Höppner, C. Burmeister, K. Lüersen, C. Betzel & E. Liebau:
Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus.
J. Mol. Biol. 377, 501-511 (2008).

R. Ponnusamy, R. Moll, T. Weimar, J.R. Mesters & R. Hilgenfeld:
Variable oligomerization modes in coronavirus non-structural protein 9.
J. Mol. Biol. 383, 1081-1096 (2008).

I. Robel, J. Gebhardt, J.R. Mesters, A. Gorbalenya, B. Coutard, B. Canard, R. Hilgenfeld & J. Rohayem:
Functional characterization of the cleavage specificity of the Sapovirus chymotrypsin-like protease.
J. Virol. 82, 8085-8093 (2008).

J.R. Mesters & R. Hilgenfeld:
Glutamate Carboxypeptidase II
In: Handbook of Metalloproteins Online Edition (A. Messerschmidt, ed.)
Wiley Interscience (2008).

R. Hilgenfeld, J. Tan, S. Chen, X. Shen & H. Jiang:
Structural proteomics of emerging viruses: The examples of SARS-CoV and other coronaviruses.
In Structural Proteomics (J. Sussman & I. Silman, eds.), 361-433 (2008).

K.H.G. Verschueren, K. Pumpor, S. Anemüller, S. Chen, J.R. Mesters & R. Hilgenfeld:
A Structural View of the Inactivation of the SARS-coronavirus main proteinase by benzotriazole esters.
Chem. Biol. 15, 597-606 (2008).

T. Klupsch, A. Walter, P. Mühlig & R. Hilgenfeld:
Combined kinetic osmometry and pyrometric microcalorimetry: Direct measurement of the protein-precipitant (salt) interaction.
Coll. Surf. A Physicochem. Eng. Aspects 318, 9-23 (2008).

T. Klupsch, A. Walter, P. Mühlig & R. Hilgenfeld:
Combined kinetic osmometry and pyrometric microcalorimetry on protein solutions: Setup and data evaluation.
Coll. Surf. A Physicochem. Eng. Aspects 318, 24-44 (2008).

M.F. Schmidt, A. Isidro-Llobet, M. Lisurek, A. El-Dahshan, J. Tan, R. Hilgenfeld & J. Rademann:
Sensitized Detection of Inhibitory Fragments and Iterative Development of Non-Peptidic Protease Inhibitors by Dynamic Ligation Screening.
Angew. Chem. Int. Ed. Engl. 47, 3275-3278 (2008).

Y. Piotrowski, R. Ponnusamy, S. Glaser, A. Daabach, R. Moll & R. Hilgenfeld:
Production of coronavirus nonstructural proteins in soluble form for crystallization.
In Methods in Molecular Biology 454: SARS- and other coronaviruses (D. Cavenagh, ed.),
Humana Press, Totowa, NJ (2008).

B. Coutard, A.E. Gorbalenya, E.J. Snijder, A.M. Leontovich, A. Poupon, X. De Lamballerie, R. Charrel, E.A. Gould, S. Gunther, H. Norder, B. Klempa, H. Bourhy, J. Rohayem, E. L'Hermite, P. Nordlund, D.I. Stuart, R.J. Owens, J.M. Grimes, P.A. Tucker, M. Bolognesi, A. Mattevi, M. Coll, T.A. Jones, J. Aqvist, T. Unge, R. Hilgenfeld, G. Bricogne, J. Neyts, P. La Colla, G. Puerstinger, J.P. Gonzalez, E. Leroy, C. Cambillau, J.L. Romette & B. Canard:
The VIZIER project: Preparedness against pathogenic RNA viruses.
Antiviral Res. 78, 37-46 (2008).

J. Rupp, J. Gieffers, M. Klinger, G. van Zandbergen, R. Wrase, M. Maass, W. Solbach, J. Deiwick & T. Hellwig-Burgel:
Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells.
Cell Microbiol. 9, 2181-2191 (2007).

J. Tan, Y. Kusov, D. Mutschall, S. Tech, K. Nagarajan, R. Hilgenfeld & C.L. Schmidt:
The "SARS-unique domain" (SUD) of SARS coronavirus is an oligo(G)-binding protein.
Biochem. Biophys. Res. Commun. 364, 877-882 (2007).

J.R. Mesters & R. Hilgenfeld:
Protein glycosylation, sweet to crystal growth?
Cryst. Growth Des. 7, 2251–2253 (2007). Free PDF-download (registering is required).

J. Wolfova, J.R. Mesters, J. Brynda, R. Grandori, A. Natalello, J. Carey & I.K. Smatanova:
Crystallization and preliminary diffraction analysis of E. coli WrbA in complex with its cofactor flavin mononucleotide.
Acta Cryst. F63, 571-575 (2007).

D. Hubmacher, B.F. Matzanke & S. Anemüller:
Iron-uptake in the Euryarchaeon Halobacterium salinarum.
BioMetals 20, 539-547 (2007).

J.R. Mesters, K. Henning & R. Hilgenfeld:
Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.
Acta Cryst. D63, 508-513 (2007).

T. Hogg & R. Hilgenfeld:
Protein Crystallography in Drug Discovery.
In: Comprehensive Medicinal Chemistry II (J.B. Taylor and D.J. Triggle, eds.)
Vol. 3 (ed. H. Kubinyi), pp. 875–900. Elsevier, Amsterdam (2007).

J. Deiwick, S.P. Salcedo, E. Boucrot, S.M. Gilliland, T. Henry, N. Petermann, S.R. Waterman, J.P. Gorvel, D.W. Holden & S. Meresse:
The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.
Infect. Immun. 74, 6965-6972 (2006).

J.R. Mesters:
Practical Protein Crystallization.
In: Principles of Protein X-Ray Crystallography (Third Edition) by Jan Drenth.
Springer Science+Business Media LLC, New York, Chapter 16, pp. 297-304 (2006).

J.R. Mesters, J. Tan & R. Hilgenfeld:
Viral enzymes.
Curr Opin Struct Biol. 16, 776-786 (2006).

G. Kaulmann, G.J. Palm, K. Schilling, R. Hilgenfeld, B. Wiederanders:
The crystal structure of a Cys25 -> Ala mutant of human procathepsin S elucidates enzyme-prosequence interactions.
Protein Sci. 15, 2619-2629 (2006).

R. Hilgenfeld, K. Anand, J.R. Mesters, Z. Rao, X. Shen, H. Jiang, J. Tan, K.H. Verschueren:
Structure and dynamics of SARS coronavirus main proteinase, (Mpro).
Adv. Exp. Med. Biol. 581, 585-591 (2006).

Y. Piotrowski, L. van der Hoek, K. Pyrc, B. Berkhout, R. Moll, R. Hilgenfeld:
Nonstructural proteins of human coronavirus NL63.
Adv. Exp. Med. Biol. 581, 97-100 (2006).

R. Ponnusamy, J.R. Mesters, J. Ziebuhr, R. Moll, R. Hilgenfeld:
Non structural proteins 8 and 9 of human coronavirus 229E.
Adv. Exp. Med. Biol. 581, 49-54 (2006).

N. Matthes, J.R. Mesters, B. Coutard, B. Canard, E. J. Snijder, R. Moll & R. Hilgenfeld:
The non-structural protein Nsp10 of Mouse Hepatitis Virus binds zinc ions and nucleic acids.
FEBS Lett. 580, 4143-4149 (2006).

J. Ondrácek & J.R. Mesters:
Ensemble of crystallographic models enabled description of novel bromate-oxoanion species, trapped within a protein crystal.
Acta Cryst. D62, 996-1001 (2006).

T. Hogg, K. Nagarajan, S. Herzberg, L. Chen, X. Shen, H. Jiang, M. Wecke, C.J. Blohmke, R. Hilgenfeld & C.L. Schmidt:
Structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite plasmodium falciparum.
J. Biol. Chem. 281, 25425-25437 (2006).

S.I. Al-Gharabli, S.T. Shah, S. Weik, M.F. Schmidt, J.R. Mesters, D. Kuhn, G. Klebe, R. Hilgenfeld & J. Rademann:
An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV M(pro)) inhibitors.
ChemBioChem 7, 1048-1055 (2006).

R. Hilgenfeld & K. Pumpor:
Sometimes intermediates do the job!
Chem. Biol. 13, 235-236 (2006) (commentary).

J.R. Mesters, C. Barinka, W. Li, T. Tsukamoto, P. Majer, B.S. Slusher, J. Konvalinka & R. Hilgenfeld:
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
EMBO J. 25, 1375-1384 (2006).

D. Schneider, CL. Schmidt:
Multiple rieske proteins in prokaryotes: Where and why?
Biochim. Biophys. Acta. 1710, 1-12 (2005).

H. Bönisch, CL. Schmidt, P. Bianco, R. Ladenstein:
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin. I. 0.69 A X-ray structure of mutant W4L/R5S.
Acta Cryst. D61, 990-1004 (2005).

S. Reindel, C.L. Schmidt, S. Anemuller & B.F. Matzanke:
Expression and regulation pattern of ferritin-like DpsA in the archaeon Halobacterium salinarum.
Biometals 18, 387-397 (2005).

J. Tan, K.H.G. Verschueren, K. Anand, J. Shen, M. Yang, Y. Xu, Z. Rao, J. Bigalke, B. Heisen, J.R. Mesters, K. Chen, X. Shen, H. Jiang & R. Hilgenfeld:
pH-dependent conformational flexibility of the SARS-CoV main proteinase (M^pro) dimer: Molecular dynamics simulations and multiple X-ray structure analyses.
J. Mol. Biol. 354, 25-40 (2005).

H. Yang, W. Xie, X. Xue, K. Yang, J. Ma, W. Liang, Q. Zhao, Z. Zhou, D. Pei, J. Ziebuhr, R. Hilgenfeld, K.Y. Yuen, L. Wong, G. Gao, S. Chen, Z. Chen, D. Ma, M. Bartlam & Z. Rao:
Design of wide-spectrum inhibitors targeting coronavirus main proteases.
PLoS Biol. 3, 1742-1752 (2005).

D. Chakravortty, M. Rohde, L. Jäger, J. Deiwick, & M. Hensel:
Formation of a novel surface structure encoded by Salmonella Pathogenicity Island 2.
EMBO J. 24, 2043-2052 (2005).

K. Anand, H. Yang, M. Bartlam, Z. Rao & R. Hilgenfeld:
Coronavirus main proteinase: target for antiviral drug therapy.
In: Coronaviruses with special emphasis on first insights concerning SARS (A. Schmidt, M.H. Wolf & O. Weber, eds). Birkhäuser, Basel, pp. 173-199 (2005).

D.A. Groneberg, R. Hilgenfeld, P. Zabel:
Molecular mechanisms of severe acute respiratory syndrome (SARS).
Respir. Res. 6, 8-23 (2005).

A. Hillisch, L.F. Pineda & R. Hilgenfeld:
Utility of homology models in the drug discovery process.
Drug Discov. Today 9, 659-669 (2004).

C. Gelhaus, R. Vicik, R. Hilgenfeld, C.L. Schmidt, M. Leippe & T. Schirmeister:
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate.
Biol. Chem. 385, 435-438 (2004).

T. Hogg, U. Mechold, H. Malke, M. Cashel, & R. Hilgenfeld:
Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.
Cell 117, 57-68 (2004).

C.L. Schmidt:
Rieske iron–sulfur proteins from extremophilic organisms.
J. Bioenerg. Biomembr. 36, 107-113 (2004).

R.G. Moll & G. Schäfer:
Novel functional aspects of the membrane-bound exo-pyrophosphatase of the hyperthermophilic Archaeon Sulfolobus are provided by analysis of its gene and the adjacent gene cluster.
J. Bioenerg. Biomembr. 36, 143-150 (2004).

R.G. Moll:
The archaeal signal recognition particle: steps towards membrane binding.
J. Bioenerg. Biomembr. 36, 47-53 (2004).

B.F. Matzanke, S. Anemüller, V. Schünemann, A.X. Trautwein & K. Hantke:
FhuF - part of a siderophore - reductase system.
Biochemistry 43, 1386-1392 (2004).

T. Klupsch, P. Mühlig & R. Hilgenfeld:
The distribution of a macromolecular solute within an evaporating drop: an exact analytical solution.
Coll. Surf. A: Physicochem. Eng. Aspects 231, 85-102 (2003).

J.H. Helbig, B. König, H. Knospe, B. Bubert, C. Yu, C.P. Lück, A. Riboldi-Tunnicliffe, R. Hilgenfeld, E. Jacobs, J. Hacker & G. Fischer:
The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells.
Biol. Chem. 384, 125-137 (2003).

H. Giersiefen, R. Hilgenfeld & A. Hillisch:
Modern methods of drug discovery: an introduction.
EXS 93 , 1-18 (2003).

A. Hillisch & R. Hilgenfeld:
The role of protein 3D-structures in the drug discovery process.
EXS 93 , 157-181 (2003).

K. Anand, J. Ziebuhr, P. Wadhwani, J.R. Mesters & R. Hilgenfeld:
Coronavirus Main Proteinase (3CL^pro) Structure: Basis for Design of Anti-SARS Drugs.
Science 300, 1763-1767 (2003).

G. Kaulmann, G.J. Palm, K. Schilling, R. Hilgenfeld & B. Wiederanders:
An unfolding/refolding step helps in the crystallization of a poorly soluble protein.
Acta Cryst. D59, 1243-1245 (2003).

R. Kohler, J. Fanghanel, B. Konig, E. Luneberg, M. Frosch, J.U. Rahfeld, R. Hilgenfeld, G. Fischer, J. Hacker, M. Steinert:
Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila.
Infect. Immun. 71, 4389-4397 (2003).

H. Yang, M. Yang, Y. Ding, Y. Liu, Z. Lou, Z. Zhou, L. Sun, L. Mo, S. Ye, H. Pang, G.F. Gao, K. Anand, M. Bartlam, R. Hilgenfeld & Z. Rao:
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor.
Proc. Natl. Acad. Sci. USA 100, 13190-13195 (2003).

T. Hettmann, S. Anemüller, H. Borcherding, L. Mathé, P. Steinrücke & S. Dieckmann:
P. stuzeri soluble Nitrate Reductase alpha-beta subunit is a soluble enzyme with a similar electronic structure at the active site as the inner membrane bound alpha-beta-gamma holoenzyme.
FEBS Lett. 534, 143-150 (2003).

D. Hubmacher, B.F. Matzanke & S. Anemüller:
Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarum.
Biol. Chem. 384, 1565-1573 (2003).

R.G. Moll:
Protein-protein, protein-RNA and protein-lipid interactions of signal-recognition particle components in the hyperthermoacidophilic archaeon Acidianus ambivalens.
Biochem. J. 374, 247-254 (2003).

A. Hiller, T. Henninger, G. Schafer & C.L. Schmidt:
New genes encoding subunits of a cytochrome bc1-analogous complex in the respiratory chain of the hyperthermoacidophilic crenarchaeon Sulfolobus acidocaldarius.
J. Bioenerg. Biomembr. 35, 121-131 (2003).

D. Schneider, C.L. Schmidt & A. Seidler:
Expression of membrane-bound iron-sulfur proteins.
Methods Mol. Biol. 228, 37-47 (2003).

H. Gruegelsiepe, D.K. Willkomm, O. Goudinakis & R.K. Hartmann:
Antisense inhibition of Escherichia coli RNase P RNA: mechanistic aspects.
ChemBioChem. 4, 1049-1056 (2003).

D.K. Willkomm, H. Gruegelsiepe, O. Goudinakis, R. Kretschmer-Kazemi Far, R. Bald, V.A. Erdmann & R.K. Hartmann:
Evaluation of bacterial RNase P RNA as a drug target.
ChemBioChem 4,1041-1048 (2003).

T. Persson, S. Cuzic & R.K. Hartmann:
Catalysis by RNase P RNA: unique features and unprecedented active site plasticity.
J. Biol. Chem. 278, 43394-43401 (2003).

R. Feltens, M. Gossringer, D.K. Willkomm, H. Urlaub & R.K. Hartmann:
An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains.
Proc. Natl. Acad. Sci. USA 100, 5724-5729 (2003).

C. Kruse, D. K. Willkomm, J. Gebken, A. Schuh, H. Stossberg, T. Vollbrandt & P.K. Müller:
The multi-KH protein vigilin associates with free and membrane-bound ribisomes.
Cell Mol. Life Sci. 60, 2219-2227 (2003).

E. Hartmann & R.K. Hartmann:
The enigma of ribonuclease P evolution.
Trends Genet. 19, 561-569 (2003).

K. Anand, G.J. Palm, J.R. Mesters, S.G. Siddell, J. Ziebuhr & R. Hilgenfeld:
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J. 21, 3213-3224 (2002).

T. Hogg, J.R. Mesters & R. Hilgenfeld:
Inhibitory Mechanisms of Antibiotics Targeting Elongation Factor Tu.
Curr. Prot. Pept. Sci. 3, 121-131 (2002).

J. Weber, J.R. Mesters, M. Lepsik, J. Prejdova, M. Svec, J. Sponarova, P. Mlcochova, K. Skalicka, K. Strisovsky, T. Uhlikova, M. Soucek, L. Machala, M. Stankova, J. Vondrasek, T. Klimkait, H.-G. Kraeusslich, R. Hilgenfeld & J. Konvalinka:
Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains.
J. Mol. Biol. 324, 739-754 (2002).

E.B. Küttner, R.Hilgenfeld & M.S. Weiss:
Purification, characterization, and crystallization of alliinase from garlic.
Arch. Biochem. Biophys. 402, 192-200 (2002).

E.B. Küttner, R. Hilgenfeld & M.S. Weiss:
The active principle of garlic at atomic resolution.
J. Biol. Chem. 277, 46402-46407 (2002).

T. Sicker & R. Hilgenfeld:
Blutgerinnungsfaktor XIII: Aktivierung, Substrate und Struktur einer Transglutaminase.
Hämostaseologie 1/2002, 8-13 (2002).

K. Anand, D.Pal & R. Hilgenfeld:
An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules.
Acta Cryst. D58, 1722-1728 (2002).

N.E. Chayen & R. Hilgenfeld:
Crystallization comes of age.
Trends Biotechn. 20, 320-321 (2002).

T. Hogg. I. Kuta Smatanova, K. Bezouska, N. Ulbrich & R. Hilgenfeld:
Sugar-mediated lattice contacts in crystals of a plant glycoprotein.
Acta Cryst. D58, 1734-1739 (2002).

M. Riess-Kautt & R. Hilgenfeld (eds.):
Proceedings of the 9th International Conference on the Crystallization of Biological Macromolecules.
Acta Cryst. D58, 1511-1764 (2002).

G. Webster & R. Hilgenfeld:
Perspectives on Single Molecule Diffraction Using the X-Ray Free Electron Laser.
Single Mol. 3, 61-66 (2002).

A. Hillisch & R. Hilgenfeld (eds.):
Modern Methods in Drug Discovery.
Birkhäuser-Verlag. Basel, ISBN 3-7643-6081-X (2002).

L. Vogeley, G.J. Palm, J.R. Mesters & R. Hilgenfeld:
Conformational change of elongation factor Tu induced by antibiotic binding: Crystal structure of the complex between EF-Tu:GDP and aurodox.
J. Biol. Chem. 276, 17149-17155 (2001).

J.R. Mesters, T. Hogg & R. Hilgenfeld:
G proteins.
In: Encyclopedia of Life Sciences. Macmillan (Nature), London, 2001 (www.els.net).

A. Ambrus, I. Banyai, M.S. Weiss, R. Hilgenfeld, Z. Keresztessy, L. Muszbek & L. Fesus:
Calcium binding to transglutaminases: A 43Ca NMR study combined with surface polarity analysis.
J. Biomol. Struct. Dyn. 19, 1-15 (2001).

M.S. Weiss, M. Brandl, J. Sühnel, D. Pal & R. Hilgenfeld:
More hydrogen bonds for the (structural) biologist.
Trends Biochem. Sci. 26, 521-523 (2001).

M. Brandl. M.S. Weiss, J. Sühnel & R. Hilgenfeld:
C-H...π interactions in proteins.
J. Mol. Biol. 307, 357-377 (2001).

A. Rau, T. Hogg, R. Marquardt & R. Hilgenfeld:
A new lysozyme fold: Structure of the muramidase from Streptomyces coelicolor at 1.65 Å resolution.
J. Biol. Chem. 276, 31994-31999 (2001).

M.S. Weiss, T. Sicker & R. Hilgenfeld:
Soft X-rays, high redundancy and proper scaling: A new procedure for automated protein structure determination via SAS.
Structure 9, 771-777 (2001).

M.S. Weiss, T. Sicker, K. Dijnovic-Carugo & R. Hilgenfeld:
On the routine use of soft X-rays in macromolecular crystallography.
Acta Cryst. D57, 689-695 (2001).

G. Webster & R. Hilgenfeld:
An evolutionary computational approach to solving the phase problem in macromolecular crystallography.
Acta Cryst. A57, 351-358 (2001).

P. Mühlig, T. Klupsch, U. Schell & R. Hilgenfeld:
Investigation of the early stages of insulin crystallization by Confocal Laser Scanning Microscopy (CLSM).
J. Cryst. Growth 232, 93-101 (2001).